Pharmacy school, Guilin Medical University, Guilin 541100, PR China; Department of Pharmacy, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, PR China.
Pharmacy school, Guilin Medical University, Guilin 541100, PR China.
Fitoterapia. 2020 Oct;146:104684. doi: 10.1016/j.fitote.2020.104684. Epub 2020 Jul 4.
A decoction of Plumeria rubra flowers has been used traditionally for the treatment of diabetes in China and Mexico. Chemical investigations on the bioactive constituents of these flowers led to the isolation of 30 compounds, including the four new compounds, one iridoiod (1), two triterpenoids (4, 5), and a long-chain δ-lactone (16). In addition, 26 known compounds (2, 3, 6-15, 17-30) are also reported. All of these compounds were identified on the basis of spectroscopic data interpretation and the absolute configurations of compound 4, 5, 16 were determined by Mosher's method. Compounds 1-4, 7, 8 and 16 showed moderate to significant inhibitory activities against α-glucosidase and protein tyrosine phosphatase 1B, with 4 having IC values of 19.45 μM and 0.21 μM, respectively.
鸡蛋花的汤剂在中国和墨西哥传统上被用于治疗糖尿病。对这些花的生物活性成分的化学研究导致了 30 种化合物的分离，包括 4 种新的化合物，1 种薁类（1），2 种三萜类（4、5）和 1 种长链 δ-内酯（16）。此外，还报道了 26 种已知化合物（2、3、6-15、17-30）。所有这些化合物都是根据光谱数据分析和莫舍尔法确定的化合物 4、5、16 的绝对构型来鉴定的。化合物 1-4、7、8 和 16 对α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 表现出中等至显著的抑制活性，其中 4 的 IC 值分别为 19.45 μM 和 0.21 μM。
