具有潜在α-葡萄糖苷酶抑制活性的诺丽果汁中的新生物碱。
New alkaloids from the noni juice with potential α-glucosidase inhibitory activity.
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 571199, China.
出版信息
Fitoterapia. 2021 Sep;153:104946. doi: 10.1016/j.fitote.2021.104946. Epub 2021 May 26.
Four new alkaloids, nonialkaloids A-D (1-4) and six known analogues (5-10) were isolated from the noni juice. Among the new compounds, 1 and 2 are indole alkaloids with a seven-membered fused N-heterocyclic ring, 3 and 4 are quaternary ammonium derivatives. The structures were elucidated by extensive NMR and MS analysis, while the absolute configurations of the stereogenic carbons were established based on quantum-chemical electronic circular dichroism calculations or the modified Mosher's method. All the isolates were tested for α-glucosidase inhibitory activities. Compounds 1 and 3 displayed potent inhibitory activity against α-glucosidase with the IC values of 413.7 and 364.4 μM, respectively.
从诺丽果汁中分离得到了 4 种新生物碱，非生物碱 A-D（1-4）和 6 种已知类似物（5-10）。在新化合物中，1 和 2 是具有七元稠合 N-杂环的吲哚生物碱，3 和 4 是季铵衍生物。通过广泛的 NMR 和 MS 分析阐明了结构，而手性碳原子的绝对构型则是基于量子化学电子圆二色谱计算或改进的 Mosher 法确定的。所有分离物均测试了对α-葡萄糖苷酶的抑制活性。化合物 1 和 3 对α-葡萄糖苷酶表现出强烈的抑制活性，IC 值分别为 413.7 和 364.4 μM。
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