Minhang Hospital and School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China; Department of Pharmaceutics, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Minhang Hospital and School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China.
Int J Pharm. 2020 Aug 30;586:119606. doi: 10.1016/j.ijpharm.2020.119606. Epub 2020 Jul 4.
Developing an all-in-one multimodal theranostic platform that can synergistically integrate sensitive photoacoustic (PA) imaging, enhanced photothermal therapy (PTT) and photodynamic therapy (PDT) as well as the nano-enzyme activated chemodynamic therapy (CDT) presents a great challenge for the current nanomedicine design. Herein, a simple hydrothermal method was used to prepare porous molybdenum disulfide (MoS) nanoflowers. These nanoflowers were assembled by three dimensional (3D)-stacked MoS nanosheets with plentiful pores and large surfaces, which thus exhibited enhanced photothermal conversion via light trapping and peroxidase (POD)-like activity via active defects exposure. Consequently, this 3D-MoS nanostructure could be well-sealed by polyethylene glycol-polyethylenimine polymer modified with nucleolar translocation signal sequence of the LIM Kinase 2 protein (LNP) via strong electrostatic interaction, which not only benefited to stably deliver anticancer drug doxorubicin (DOX) into the tumor cells for pH/NIR-responsive chemotherapy, but also provided strong photoacoustic, photothermal performances and stimulated generation of reactive oxygen species (ROS) for imaging-guided PTT/PDT/CDT combined therapy. This work promised a simple all-in-one multimodal theranostic platform to augment the potential antitumoral therapeutic outcomes.
开发一种集敏感光声（PA）成像、增强光热治疗（PTT）和光动力治疗（PDT）以及纳米酶激活化学动力学治疗（CDT）于一体的多功能治疗平台，这对当前的纳米医学设计提出了巨大挑战。在此，我们采用一种简单的水热法制备了多孔二硫化钼（MoS）纳米花。这些纳米花由三维（3D）堆叠的 MoS 纳米片组装而成，具有丰富的孔隙和较大的表面积，因此通过光捕获增强了光热转换，并通过暴露活性缺陷增强了过氧化物酶（POD）样活性。因此，这种 3D-MoS 纳米结构可以通过聚乙二醇-聚亚乙基亚胺聚合物与 LIM 激酶 2 蛋白（LNP）的核仁易位信号序列进行强力静电相互作用而被很好地密封，这不仅有利于将抗癌药物阿霉素（DOX）稳定地递送至肿瘤细胞中进行 pH/NIR 响应的化学疗法，而且还提供了强大的光声、光热性能，并刺激产生活性氧（ROS）用于成像引导的 PTT/PDT/CDT 联合治疗。这项工作为增强潜在的抗肿瘤治疗效果提供了一种简单的一体化多模态治疗平台。
