C6-取代的 UDP-GlcNAc 衍生物的合成。
Synthesis of C6-substituted UDP-GlcNAc derivatives.
机构信息
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6, Canada.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6, Canada.
出版信息
Carbohydr Res. 2020 Sep;495:108071. doi: 10.1016/j.carres.2020.108071. Epub 2020 Jun 26.
UDP-sugar analogs are useful for the study of glycosyltransferases and the production of unnatural glycans. The preparation of five UDP-GlcNAc derivatives is reported with 6-deoxy, 6-azido, 6-amino, 6-mercapto, or 6-fluoro substitutions. A concise chemoenzymatic synthesis was developed using the kinase NahK (B. longum JCM1217) and the uridyl transferase GlmU (E. coli K12).
UDP-糖类似物可用于糖基转移酶的研究和非天然聚糖的生产。本文报道了 5 种 UDP-GlcNAc 衍生物的制备，其中包括 6-脱氧、6-叠氮、6-氨基、6-巯基或 6-氟取代基。利用激酶 NahK（长双歧杆菌 JCM1217）和尿苷酰转移酶 GlmU（大肠杆菌 K12），开发了一种简洁的化学酶合成方法。
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