Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States; Center for Computational Biology, University of California, Berkeley, CA, United States.
Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States; Center for Computational Biology, University of California, Berkeley, CA, United States.
Curr Opin Genet Dev. 2020 Jun;62:58-64. doi: 10.1016/j.gde.2020.05.028. Epub 2020 Jul 4.
Germline mutations are the source of all heritable variation. In the past few years, whole genome sequencing has allowed direct and comprehensive surveys of mutation patterns in humans and other species. These studies have documented substantial variation in both mutation rates and spectra across primates, the causes of which remain unclear. Here, we review what is currently known about mutation rates in primates, highlight the factors proposed to explain the variation across species, and discuss some implications of these findings on our understanding of the chronology of primate evolution and the process of mutagenesis.
种系突变是所有可遗传变异的源头。在过去的几年中，全基因组测序技术已经可以直接、全面地检测人类和其他物种的突变模式。这些研究记录了灵长类动物中突变率和突变谱的大量变化，但原因尚不清楚。本文综述了目前已知的灵长类动物突变率，强调了用于解释物种间变异的因素，并讨论了这些发现对我们理解灵长类动物进化时间进程和诱变过程的意义。
