Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain.
Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain; Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010, Barcelona, Spain; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, c/ Columnes s/n, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Curr Opin Genet Dev. 2020 Jun;62:65-71. doi: 10.1016/j.gde.2020.06.006. Epub 2020 Jul 4.
The study of primate comparative genomics has long been a focus of research, particularly in the context of understanding human evolutionary history. Recently, high-throughput methods have become accessible that allow us to tackle these questions at scale by comparing genomes within and between species, or looking at gene regulatory and expression changes between species and tissues. This burst in large-scale genomic studies has drastically increased the resolution at which we are now able to understand the evolutionary forces acting upon our own species. Furthermore, the drop in sequencing costs has made it possible to go beyond generating datasets that focus purely on human biology, and to begin incorporating larger genomic studies of non-human primates. Here, we give an overview of recent advances in large-scale high-throughput studies across the whole primate radiation.
灵长类比较基因组学的研究一直是研究的重点,特别是在了解人类进化历史的背景下。最近,高通量方法变得可行,通过在物种内和物种间比较基因组,或在物种和组织间观察基因调控和表达变化,我们可以大规模地解决这些问题。这种大规模基因组研究的爆发极大地提高了我们理解作用于我们自身物种的进化力量的分辨率。此外,测序成本的下降使得我们不仅能够生成纯粹关注人类生物学的数据集,而且还能够开始纳入更大规模的非人类灵长类动物基因组研究。在这里,我们概述了整个灵长类动物辐射范围内的高通量大规模研究的最新进展。