Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Nat Rev Genet. 2014 May;15(5):347-59. doi: 10.1038/nrg3707. Epub 2014 Apr 8.
Advances in genome sequencing technologies have created new opportunities for comparative primate genomics. Genome assemblies have been published for various primate species, and analyses of several others are underway. Whole-genome assemblies for the great apes provide remarkable new information about the evolutionary origins of the human genome and the processes involved. Genomic data for macaques and other non-human primates offer valuable insights into genetic similarities and differences among species that are used as models for disease-related research. This Review summarizes current knowledge regarding primate genome content and dynamics, and proposes a series of goals for the near future.
基因组测序技术的进步为比较灵长类动物基因组学创造了新的机会。已经发表了各种灵长类动物的基因组组装，并且正在进行其他几个基因组的分析。大型猿类的全基因组组装为人类基因组的进化起源以及涉及的过程提供了令人瞩目的新信息。猕猴和其他非人类灵长类动物的基因组数据为研究疾病相关模型的物种间遗传相似性和差异提供了有价值的见解。这篇综述总结了目前关于灵长类基因组内容和动态的知识，并为不久的将来提出了一系列目标。
