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灵长类动物的多样性:从生物医学到保护基因组学。

The Diversity of Primates: From Biomedicine to Conservation Genomics.

机构信息

Institut de Biologia Evolutiva, Pompeu Fabra University and Spanish National Research Council, 08003 Barcelona, Spain; email:

Sequencing Unit, National Genomic Analysis Center, Centre for Genomic Regulation, Barcelona Institute of Science, 08036 Barcelona, Spain.

出版信息

Annu Rev Anim Biosci. 2021 Feb 16;9:103-124. doi: 10.1146/annurev-animal-061220-023138. Epub 2020 Nov 16.

Abstract

Until now, the field of primate genomics has focused on two major themes: understanding human evolution and advancing biomedical research. We propose that it is now time for a third theme to receive attention: conservation genomics. As a result of anthropogenic effects, the majority of primate species have become threatened with extinction. A more robust primate conservation genomics will allow for genetically informed population management. Thanks to a steady decline in the cost of sequencing, it has now become feasible to sequence whole primate genomes at the population level. Furthermore, technological advances in noninvasive genomic methods have made it possible to acquire genome-scale data from noninvasive biomaterials. Here, we review recent advances in the analysis of primate diversity, with a focus on genomic data sets across the radiation.

摘要

迄今为止,灵长类基因组学领域主要关注两个主题:一是理解人类进化,二是推进生物医学研究。我们提出,现在应该关注第三个主题:保护基因组学。由于人为因素的影响,大多数灵长类物种都面临灭绝的威胁。更强大的灵长类保护基因组学将允许进行遗传知情的种群管理。由于测序成本的稳步下降,现在已经可以在种群水平上对整个灵长类基因组进行测序。此外,非侵入性基因组方法的技术进步使得从非侵入性生物材料中获取基因组规模的数据成为可能。在这里,我们回顾了灵长类多样性分析的最新进展,重点是整个辐射范围内的基因组数据集。

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