The Applied Science & Performance Institute, Research Division, Tampa, FL 33607, USA.
Animal Nutrition Department, School of Veterinary Medicine, Firat University, Elazig 23200, Turkey.
Nutrients. 2020 Jul 4;12(7):1990. doi: 10.3390/nu12071990.
The purpose of this study was to investigate the impact of antioxidant-rich marine phytoplankton supplementation (Oceanix, OCX) on performance and muscle damage following a cross-training event in endurance-trained subjects. Additionally, an animal model was carried out to assess the effects of varying dosages of OCX, with exercise, on intramuscular antioxidant capacity.
In the human trial, endurance-trained subjects (average running distance = 29.5 ± 2.6 miles × week) were randomly divided into placebo (PLA) and OCX (25 mg) conditions for 14 days. The subjects were pre-tested on a one-mile uphill run, maximal isometric strength, countermovement jump (CMJ) and squat jump (SJ) power, and for muscle damage (creatine kinase (CK)). On Day 12, the subjects underwent a strenuous cross-training event. Measures were reassessed on Day 13 and 14 (24 h and 48 h Post event). In the animal model, Wistar rats were divided into four groups ( = 7): (i) Control (no exercise and placebo (CON)), (ii) Exercise (E), (iii) Exercise + OCX 1 (Oceanix, 2.55 mg/day, (iv) Exercise + OCX 2 (5.1 mg/day). The rats performed treadmill exercise five days a week for 6 weeks. Intramuscular antioxidant capacity (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px)) and muscle damage (CK and myoglobin (MYOB) were collected. The data were analyzed using repeated measures ANOVA and -test for select variables. The alpha value was set at < 0.05.
For the human trial, SJ power lowered in PLA relative to OCX at 24 h Post (-15%, < 0.05). Decrements in isometric strength from Pre to 48 h Post were greater in the PLA group (-12%, < 0.05) than in the OCX. Serum CK levels were greater in the PLA compared to the OCX (+14%, < 0.05). For the animal trial, the intramuscular antioxidant capacity was increased in a general dose-dependent manner (E + Oc2 > E + Oc1 > E > CON). Additionally, CK and MYOB were lower in supplemented compared to E alone.
Phytoplankton supplementation (Oceanix) sustains performance and lowers muscle damage across repeated exercise bouts. The ingredient appears to operate through an elevating oxidative capacity in skeletal muscle.
本研究旨在探讨富含抗氧化剂的海洋浮游植物补充剂（Oceanix，OCX）对耐力训练受试者交叉训练后表现和肌肉损伤的影响。此外，还进行了动物模型研究，以评估 OCX 剂量变化与运动对肌肉内抗氧化能力的影响。
在人体试验中，将耐力训练的受试者（平均跑步距离= 29.5 ± 2.6 英里×周）随机分为安慰剂（PLA）和 OCX（25mg）组，持续 14 天。受试者在一英里上坡跑、最大等长力量、反跳（CMJ）和深蹲跳（SJ）力量以及肌肉损伤（肌酸激酶（CK））方面进行预测试。在第 12 天，受试者进行了剧烈的交叉训练。第 13 天和第 14 天（运动后 24 小时和 48 小时）重新评估了测量结果。在动物模型中，将 Wistar 大鼠分为四组（每组 7 只）：（i）对照组（无运动和安慰剂（CON）），（ii）运动组（E），（iii）运动+OCX1（Oceanix，2.55mg/天），（iv）运动+OCX2（5.1mg/天）。大鼠每周进行 5 天的跑步机运动。收集肌肉内抗氧化能力（超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px））和肌肉损伤（CK 和肌红蛋白（MYOB））。使用重复测量方差分析和 -检验对选择变量进行分析。设定 α 值为<0.05。
对于人体试验，与 OCX 相比，PLA 在 24 小时后 SJ 功率降低（-15%，<0.05）。与 OCX 相比，PLA 组在 48 小时后从预到后等长力量的下降幅度更大（-12%，<0.05）。与 OCX 相比，PLA 组的血清 CK 水平更高（+14%，<0.05）。对于动物试验，肌肉内抗氧化能力呈普遍的剂量依赖性增加（E+Oc2>E+Oc1>E>CON）。此外，与单独的 E 相比，补充剂降低了 CK 和 MYOB。
浮游植物补充剂（Oceanix）可维持多次运动后的表现并降低肌肉损伤。该成分似乎通过提高骨骼肌的氧化能力起作用。
