Unité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, Belgium.
Int J Mol Sci. 2020 Jul 4;21(13):4767. doi: 10.3390/ijms21134767.
Pancreatic cancer is a very aggressive cancer type associated with one of the poorest prognostics. Despite several clinical trials to combine different types of therapies, none of them resulted in significant improvements for patient survival. Pancreatic cancers demonstrate a very broad panel of resistance mechanisms due to their biological properties but also their ability to remodel the tumour microenvironment. Radiotherapy is one of the most widely used treatments against cancer but, up to now, its impact remains limited in the context of pancreatic cancer. The modern era of radiotherapy proposes new approaches with increasing conformation but also more efficient effects on tumours in the case of charged particles. In this review, we highlight the interest in using charged particles in the context of pancreatic cancer therapy and the impact of this alternative to counteract resistance mechanisms.
胰腺癌是一种侵袭性很强的癌症，预后通常较差。尽管有几项临床试验试图联合应用不同类型的疗法，但都未能显著提高患者的生存率。由于其生物学特性以及重塑肿瘤微环境的能力，胰腺癌表现出广泛的耐药机制。放射治疗是最广泛应用的癌症治疗方法之一，但到目前为止，其在胰腺癌治疗中的效果仍然有限。放射治疗的现代时代提出了新的方法，在提高适形性的同时，对肿瘤也有更有效的作用，特别是在使用带电粒子的情况下。在这篇综述中，我们强调了在胰腺癌治疗中使用带电粒子的意义，并探讨了这种替代方法对克服耐药机制的影响。
