Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.
Cells. 2020 Jul 5;9(7):1620. doi: 10.3390/cells9071620.
Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription.
转录增强子是真核生物中控制基因活性的主要基因组元件。最近的研究深入了解了核中转录的时空组织、非编码 RNA 在该过程中的作用以及基因表达的表观遗传控制。因此，增强子功能的多个分子细节被揭示出来。在这里，我们描述了增强子驱动转录的分子组织的最新数据和模型。
