IBM Research Europe, Säumerstrasse 4, CH-8803 Rüschlikon, Switzerland.
Institute for Chemical and Bioengineering, Dept. of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule (ETH-Zürich), Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland.
Anal Chem. 2020 Sep 1;92(17):11548-11552. doi: 10.1021/acs.analchem.0c02176. Epub 2020 Jul 27.
We present a novel method for the local retrieval of surface bound species and their rapid in-line separation using an open space microfluidic device. Separation can be performed in less than 30 s using the difference in diffusivities within parallel microfluidic flows. As a proof-of-principle, we report the rapid and efficient filtration of polystyrene beads from small molecules and surface bound red blood cells from dimethyl sulfoxide for antigen typing.
我们提出了一种新颖的方法，可利用开放式微流控装置实现表面结合物种的局部提取及其快速在线分离。通过平行微流道中扩散系数的差异，可在不到 30 秒的时间内完成分离。作为原理验证，我们报告了从小分子中快速有效地过滤聚苯乙烯珠以及从二甲基亚砜中过滤表面结合的红细胞，以进行抗原分型。
