Guangdong Medical University, Zhanjiang, PR China.
The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, PR China.
Lupus. 2020 Sep;29(10):1189-1197. doi: 10.1177/0961203320938447. Epub 2020 Jul 7.
The objective of this study was to explore the association between periodontitis and systemic lupus erythematosus (SLE).
To identify eligible studies, the PubMed, EMBASE and Web of Science databases were searched from inception to 19 September 2019. Associations of periodontitis, and other periodontal parameters, with SLE were assessed.
Ten studies involving 80,633 subjects were included in this meta-analysis. Pooled data showed a significant association between periodontitis and SLE (odds ratio=5.32, 95% confidence interval (CI) 1.69-16.78, = 0.004). In addition, SLE patients had a higher prevalence of bleeding on probing (mean difference = 0.03, 95% CI 0.00-0.06, = 0.02) and higher mean clinical attachment loss (mean difference = 0.69, 95% CI 0.39-1.00, < 0.001). However, there were no significant differences between SLE and reference subjects in mean plaque index, gingival index, pocket depth or decayed, missing or filled teeth.
This study demonstrates a significant association between periodontitis and SLE, which indicates that avoidance of periodontitis by maintaining oral health may be a simple and economical way to prevent SLE.
本研究旨在探讨牙周炎与系统性红斑狼疮（SLE）之间的关联。
为了确定合格的研究，从建库到 2019 年 9 月 19 日，我们在 PubMed、EMBASE 和 Web of Science 数据库中进行了检索。评估了牙周炎和其他牙周参数与 SLE 的相关性。
本荟萃分析共纳入了 10 项涉及 80633 名受试者的研究。汇总数据显示，牙周炎与 SLE 之间存在显著相关性（比值比=5.32，95%置信区间[CI]1.69-16.78，=0.004）。此外，SLE 患者的探诊出血患病率较高（平均差值=0.03，95%CI0.00-0.06，=0.02），平均临床附着丧失较高（平均差值=0.69，95%CI0.39-1.00，<0.001）。然而，SLE 患者与参照人群的平均菌斑指数、牙龈指数、牙周袋深度或龋齿、缺失或补牙无显著差异。
本研究表明牙周炎与 SLE 之间存在显著关联，这表明通过保持口腔健康来预防牙周炎可能是预防 SLE 的一种简单且经济的方法。
