Ziglioli Francesco, Baciarello Marco, Maspero Giada, Bellini Valentina, Bocchialini Tommaso, Cavalieri Domenico, Bignami Elena Giovanna, Maestroni Umberto
Department of Urology, University-Hospital of Parma, Via Gramsci, 14, Parma, Italy.
Anesthesia, Intensive Care and Pain Therapy Service, University-Hospital of Parma, Via Gramsci, 14, Parma, Italy.
Ann Med Surg (Lond). 2020 May 30;56:110-115. doi: 10.1016/j.amsu.2020.05.029. eCollection 2020 Aug.
Prostate cancer is considered one of the most important health problems. Due to the increased number of diagnosed patients and the inability to distinguish aggressive tumors, minimally-invasive procedures have become increasingly interesting. High-intensity focused ultrasound (HIFU) is an alternative option to radical surgery to treat prostate cancer. To date, however, data on side effects and comorbidities of this technique are still not conclusive.
We reviewed the literature to concentrate on side effects and comorbidities of HIFU treatment of prostate cancer with the following key words: hifu, high intensity focused ultrasound, ultrasonic therapy, transrectal hifu, prostate ablation, side effects, comorbidities. MedLine and Embase via Ovid database were searched. Selection criteria were: English language, articles published between 2001 and 2015, case series including at least 100 participants and reported data on side effects and comorbidities. Sixteen uncontrolled studies were identified. No randomized controlled trials (RCT) were found in the literature comparing side effects and comorbidities of HIFU to other routine approaches to prostate cancer treatment.
HIFU seems to be a promising minimally-invasive treatment for low- and intermediate-risk prostate cancer, especially for patients who are unfit for radical surgery. Prospective studies with longer follow-up periods and RCT are required to properly assess the impact of side effects and comobidities related to the HIFU technique in comparison with other therapies to treat prostate cancer.
前列腺癌被认为是最重要的健康问题之一。由于确诊患者数量增加以及无法区分侵袭性肿瘤，微创治疗方法变得越来越受关注。高强度聚焦超声（HIFU）是治疗前列腺癌的一种替代根治性手术的选择。然而，迄今为止，关于该技术的副作用和合并症的数据仍不确凿。
我们通过以下关键词检索文献，以聚焦HIFU治疗前列腺癌的副作用和合并症：hifu、高强度聚焦超声、超声治疗、经直肠HIFU、前列腺消融、副作用、合并症。通过Ovid数据库检索了MedLine和Embase。选择标准为：英文文献、2001年至2015年间发表的文章、至少包含100名参与者的病例系列以及报告的副作用和合并症数据。共识别出16项非对照研究。文献中未发现将HIFU与其他常规前列腺癌治疗方法的副作用和合并症进行比较的随机对照试验（RCT）。
HIFU似乎是一种有前景的低危和中危前列腺癌微创治疗方法，尤其适用于不适合根治性手术的患者。需要进行更长随访期的前瞻性研究和RCT，以与其他治疗前列腺癌的方法相比，正确评估与HIFU技术相关的副作用和合并症的影响。
