Bale J F, Wilson J F, Hill H R
Cancer. 1977 Jun;39(6):2386-90. doi: 10.1002/1097-0142(197706)39:6<2386::aid-cncr2820390612>3.0.co;2-x.
A 10-year-old girl with eczema, asthma, recurrent abscesses, middle ear infections and pneumonias developed a histiocytic lymphoma of the brain. Immunologic evaluation revealed hyperimmunoglobulinemia E, depressed neutrophil chemotaxis, absent delayed hypersensitivity skin test tests, low T-lymphocyte numbers and depressed in vitro lymphocyte responses. The occurrence in this patient of a histiocytic lymphoma, which is commonly associated with more classic immunodeficiency syndromes or immunosuppression for transplantation, suggests that individuals with hyperimmunoglobulinemia E and recurrent infections may also be at increased risk for developing unusual malignancies.
一名患有湿疹、哮喘、反复出现脓肿、中耳感染和肺炎的10岁女孩患上了脑组织细胞淋巴瘤。免疫评估显示有高免疫球蛋白E血症、中性粒细胞趋化性降低、迟发性超敏皮肤试验缺失、T淋巴细胞数量低以及体外淋巴细胞反应降低。该组织细胞淋巴瘤通常与更典型的免疫缺陷综合征或移植免疫抑制相关，而在这名患者身上出现，这表明高免疫球蛋白E血症和反复感染的个体发生罕见恶性肿瘤的风险可能也会增加。
