Mushtaq Sabha, Sarkar Rashmi
Department of Dermatology, Venereology & Leprology, Government Medical College, Jammu, Jammu & Kashmir, India.
Department of Dermatology, Venereology & Leprology, Maulana Azad Medical College, New Delhi, India.
Int J Womens Dermatol. 2020 Feb 13;6(3):191-198. doi: 10.1016/j.ijwd.2020.01.009. eCollection 2020 Jun.
Sulfasalazine is an aminosalicylate primarily used in the treatment of rheumatoid arthritis and ulcerative colitis. Its immunomodulatory, anti-inflammatory, and antiproliferative properties make it a potential therapeutic option for various dermatological disorders. Owing to its wide range of effects, it is often used off-label in dermatological diseases, such as alopecia areata, psoriasis and psoriatic arthritis, lichen planus, and pemphigus. However, the level of evidence supporting its efficacy and safety in dermatology is limited. More research is needed to uncover the full potential of sulfasalazine in dermatology. The present article is a detailed review of the pharmacology, modes of action, side effects, and contraindications of sulfasalazine, along with an up-to-date review of the evidence underlying its use in various dermatological conditions.
柳氮磺胺吡啶是一种氨基水杨酸酯，主要用于治疗类风湿性关节炎和溃疡性结肠炎。其免疫调节、抗炎和抗增殖特性使其成为各种皮肤病潜在的治疗选择。由于其作用广泛，它常被用于治疗斑秃、银屑病和银屑病关节炎、扁平苔藓和天疱疮等皮肤病，但未按药品说明书用药。然而，支持其在皮肤科疗效和安全性的证据水平有限。需要更多研究来揭示柳氮磺胺吡啶在皮肤科的全部潜力。本文详细综述了柳氮磺胺吡啶的药理学、作用方式、副作用和禁忌证，以及对其在各种皮肤病中应用证据的最新综述。
