Chen Michael L, Chlopik Agata, Hoang Maija P, Smith Gideon P
Harvard University, Cambridge, Massachusetts, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. michael_
Dermatol Online J. 2017 Oct 15;23(10):13030/qt8267v8v9.
Erythema elevatum diutinum (EED) is a rare, chronic small-vessel vasculitis that presents as firm, red, violaceous, or brown papules and nodules on the extensor surfaces of the limbs. Oral dapsone is considered first-line therapy for EED; in the current case report, a patient presenting with EED began dapsone treatment and symptoms subsided within two weeks. Seven months later, the patient became pregnant and stopped dapsone owing to her concerns with dapsone use during pregnancy, resulting in recurrence of EED symptoms. We present a novel treatment approach with oral sulfasalazine, which was given to the patient in lieu of dapsone and resulted in complete resolution of EED symptoms.
持久性隆起性红斑（EED）是一种罕见的慢性小血管炎，表现为四肢伸侧出现坚实的红色、紫红色或褐色丘疹及结节。口服氨苯砜被认为是EED的一线治疗方法；在本病例报告中，一名患有EED的患者开始使用氨苯砜治疗，症状在两周内消退。七个月后，该患者怀孕，因担心孕期使用氨苯砜而停用，导致EED症状复发。我们提出了一种口服柳氮磺胺吡啶的新治疗方法，该方法代替氨苯砜给予患者，使EED症状完全缓解。
