Gao Yi, Xu Lei, Zhao Yang, You Zhengwei, Guan Qingbao
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-dimension Materials (Donghua University), College of Materials Science and Engineering, Donghua University, Shanghai, 201620, PR China.
Center for Combustion Energy and Key Laboratory for Thermal Science and Power Engineering of MOE, Tsinghua University, Beijing, 100084, China.
Bioact Mater. 2020 Jun 22;5(4):798-807. doi: 10.1016/j.bioactmat.2020.05.006. eCollection 2020 Dec.
The diversity of biomedical applications makes stereolithographic (SL) three-dimensional (3D) printing process complex. A strategy was developed to simulate the layer-by-layer fabrication of 3D printed products combining polymerization kinetic with reaction conditions to realize print preview. As a representative example, the typical UV-curable dental materials based on epoxy acrylate and photoinitiator with different molar ratios was exposed under varying intensity of UV light to verify the simulation results. A theoretical kinetics model containing oxygen inhibition was established. In-situ FTIR was employed to measure propagation and termination constants while coupled UV/vis was performed to examine the law of light attenuation during cure reaction, even with various colours and additives. Simulation results showed that the correlation coefficient square between the experiments and simulations of epoxy acrylate with 1%, 2% and 3% initiator upon 20 mW/cm UV light are 0.8959, 0.9324 and 0.9337, respectively. Consequently, our simulation of photopolymerization for SL 3D printing successfully realized visualization of printing quality before practically printing the targeted biomedical objects with complex topology structures.
生物医学应用的多样性使得立体光刻（SL）三维（3D）打印过程变得复杂。我们开发了一种策略，将聚合动力学与反应条件相结合，对3D打印产品的逐层制造过程进行模拟，以实现打印预览。作为一个典型例子，基于具有不同摩尔比的环氧丙烯酸酯和光引发剂的典型紫外光固化牙科材料，在不同强度的紫外光下曝光，以验证模拟结果。建立了一个包含氧抑制的理论动力学模型。采用原位傅里叶变换红外光谱（FTIR）测量增长和终止常数，同时进行紫外/可见光谱联用，以研究固化反应过程中的光衰减规律，即使材料具有各种颜色和添加剂。模拟结果表明，在20 mW/cm的紫外光下，引发剂含量为1%、2%和3%的环氧丙烯酸酯的实验值与模拟值之间的相关系数平方分别为0.8959、0.9324和0.9337。因此，我们对SL 3D打印光聚合的模拟成功地实现了在实际打印具有复杂拓扑结构的目标生物医学物体之前，对打印质量的可视化。
