卵泡晚期孕酮水平对体外受精-卵胞浆内单精子注射结局的影响：病例对照研究。
The impact of late follicular progesterone level on in vitro fertilization-intracytoplasmic sperm injection outcome: Case-control study.
作者信息
Novia Diana, Putri Lubis Hilma, Halim Binarwan, Pustimbara Anantya, Lestari Retno, Abinawanto Abinawanto, Bowolaksono Anom
机构信息
Department of Biology, Faculty of Mathematics and Science, University of Indonesia, Depok, Indonesia.
Halim Fertility Center, Stella Maris Women and Children Hospital, Medan, Indonesia.
出版信息
Int J Reprod Biomed. 2020 May 31;18(5):367-374. doi: 10.18502/ijrm.v13i5.7157. eCollection 2020 May.
BACKGROUND
Studies have been conducted to improve the pregnancy rate through the in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) program. In recent years, researchers have been focusing on finding impact of high progesterone level on endometrial receptivity. However, data on whether progesterone level also affects the quality of the embryo is still limited.
OBJECTIVE
The aim is to assess the effect of late follicular progesterone level on the outcome of in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI).
MATERIALS AND METHODS
This was a case-control of 245 women who underwent in vitro fertilization cycle at Halim Fertility Center, Indonesia. The outcomes assessed were number of oocytes retrieved (OR), maturation rate (MR), fertilization rate (FR), number of good embryos (GE), number of fair embryos (FE), and number of poor embryos (PE). The progesterone (P4) and estradiol (E2) levels were analyzed on the day of human chorionic gonadotropin injection. Serum progesterone level was divided into three groups: 1. low progesterone ( 0.50 ng/ml), 2. normal progesterone (0.51-1.50 ng/ml), and 3. high progesterone ( 1.50 ng/ml). All outcomes were compared amongst the groups.
RESULTS
Significant differences occurred between progesterone level on the day of human chorionic gonadotropin administration. The number of OR in group 1, 2, and 3 were 8.41 5.88 vs. 12.99 8.51 vs. 17.58 9.52, respectively.
CONCLUSION
Progesterone level on the day of human chorionic gonadotropin injection may have an impact on the outcome of IVF-ICSI.
背景
已开展多项研究以通过体外受精（IVF）和卵胞浆内单精子注射（ICSI）程序提高妊娠率。近年来，研究人员一直致力于探究高孕酮水平对子宫内膜容受性的影响。然而，关于孕酮水平是否也会影响胚胎质量的数据仍然有限。
目的
旨在评估卵泡晚期孕酮水平对体外受精 - 卵胞浆内单精子注射（IVF - ICSI）结局的影响。
材料与方法
这是一项针对245名在印度尼西亚哈利姆生育中心接受体外受精周期治疗的女性的病例对照研究。评估的结局指标包括回收的卵母细胞数量（OR）、成熟率（MR）、受精率（FR）、优质胚胎数量（GE）、中等胚胎数量（FE）和劣质胚胎数量（PE）。在注射人绒毛膜促性腺激素当天分析孕酮（P4）和雌二醇（E2）水平。血清孕酮水平分为三组：1. 低孕酮（≤0.50 ng/ml），2. 正常孕酮（0.51 - 1.50 ng/ml），3. 高孕酮（≥1.50 ng/ml）。对所有组间的结局进行比较。
结果
在注射人绒毛膜促性腺激素当天，孕酮水平之间存在显著差异。第1组、第2组和第3组的OR数量分别为8.41±5.88、12.99±8.51和17.58±9.52。
结论
注射人绒毛膜促性腺激素当天的孕酮水平可能会对IVF - ICSI的结局产生影响。
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