Venencie P Y, Boffa G A, Delmas P D, Verola O, Benkaïdali I, Frija J, Pillet B, Puissant A
Unité de Dermatologie, Centre Hospitalier Universitaire, Bicêtre, France.
Arch Dermatol. 1988 Dec;124(12):1831-4.
We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.
我们评估了一位患有厚皮性骨膜病并伴有贫血和胃肥大的患者。贫血的机制似乎是多因素的，因为除了骨髓纤维化外，还检测到一种红细胞生成后期的血清抑制剂。血清骨钙素升高支持了原发性肥大性骨关节病代表成骨细胞骨形成增加与正常骨吸收之间失衡的假说。
