[无骨髓纤维化的髓外造血性厚皮性骨膜病]
[Pachydermoperiostosis with extramedullary hematopoiesis without myelofibrosis].
作者信息
Venencie P Y, Blanchet P, Mallet V, Chantome A, Quillard J, Croisille L, Lavabre C, Tchernia G, Bouchard P, Benoit G
机构信息
Unité de Dermatologie, CHU Bicêtre, Le Kremlin Bicêtre.
出版信息
Ann Dermatol Venereol. 1998 Mar;125(3):193-5.
BACKGROUND
In three previous reports of primary hypertrophic osteoarthropathy, an associated extramedullary hematopoiesis was related to myelofibrosis.
CASE REPORT
A 44-year-old male patient with primary hypertrophic osteoarthropathy diagnosed when he was 34-year-old was referred to our hospital with an abdominal mass fortuitously detected.
DISCUSSION
The present case is unique for the patient developed an extramedullary hematopoïesis without associated myelofibrosis. It suggests the possible intervention of growth factors common to the skin fibroblasts and the blood progenitor cells in the pathogenesis of primary osteoarthropathy.
背景
在之前三篇关于原发性肥大性骨关节病的报告中，相关的髓外造血与骨髓纤维化有关。
病例报告
一名44岁男性患者，34岁时被诊断为原发性肥大性骨关节病，因偶然发现腹部肿块而转诊至我院。
讨论
本病例独特之处在于患者出现了无相关骨髓纤维化的髓外造血。这提示在原发性骨关节病的发病机制中，皮肤成纤维细胞和血液祖细胞共有的生长因子可能起到了干预作用。
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