Virginia Commonwealth University School of Medicine, Division of Urology, Department of Surgery, Richmond, VA, USA.
Virginia Commonwealth University School of Engineering, Department of Mechanical and Nuclear Engineering, Richmond, VA, USA.
Minerva Urol Nephrol. 2021 Oct;73(5):655-661. doi: 10.23736/S2724-6051.20.03838-2. Epub 2020 Jul 7.
Multichannel urodynamics is the gold standard for the evaluation of lower urinary tract symptoms (LUTS). When performing studies to validate new adjuncts to urodynamic testing with control patients undergoing urodynamic investigation, there is difficulty in the interpretation of urodynamic results in the asymptomatic patient due to artifacts and the invasive nature of the procedure. The purpose of this investigation was to examine urodynamics in asymptomatic volunteers in order to better understand the role of control participants in urodynamic research studies.
Asymptomatic volunteers with no LUTS were recruited to undergo standard urodynamic testing as a comparison group in a study evaluating novel urodynamic techniques. To be eligible, participants had to report no LUTS, score ≤1 on all symptom questions of the International Consultation on Incontinence Questionnaire Overactive Bladder Module (ICIq-OAB) survey, have no medical conditions or to undergo any medications that affect bladder function. The urodynamics was done according to ICS standards. All tracings were evaluated by an expert neuro-urologist. Data were analyzed categorically for the presence or absence of low compliance (<30 mL/cmH
A total of 24 participants completed the study including 10 men and 14 women. All participants had at least 1 urodynamic abnormality/artifact with an average of 4.43±1.28 abnormalities/participant. The most common abnormalities included uncoordinated electromyography (EMG) activity (87.50%), straining to void (79.17%), and intermittent flow (70.83%). There were no significant differences for sex, age, Body Mass Index.
This study demonstrated that healthy, asymptomatic volunteers have high rates of abnormal urodynamic findings, suggesting that asymptomatic participants are not the ideal controls in research studies that involve urodynamic testing.
多通道尿动力学检查是评估下尿路症状（LUTS）的金标准。当使用控制患者进行尿动力学检查来验证新的尿动力学检查辅助方法时，由于伪影和程序的侵入性，无症状患者的尿动力学结果的解释存在困难。本研究旨在检查无症状志愿者的尿动力学，以更好地了解对照组在尿动力学研究中的作用。
招募无症状且无 LUTS 的志愿者作为评估新型尿动力学技术研究的对照组，进行标准尿动力学检查。参与者必须报告没有 LUTS，国际尿失禁咨询问卷下尿路症状模块（ICIq-OAB）调查的所有症状问题得分为≤1，没有影响膀胱功能的医疗状况或服用任何药物。尿动力学检查按照国际尿控协会（ICS）标准进行。所有描记均由一位专家神经泌尿科医生进行评估。根据有无低顺应性（<30 mL/cmH
共有 24 名参与者完成了这项研究，其中包括 10 名男性和 14 名女性。所有参与者至少有 1 种尿动力学异常/伪影，平均每个参与者有 4.43±1.28 种异常/参与者。最常见的异常包括不协调的肌电图（EMG）活动（87.50%）、排尿时用力（79.17%）和间歇性排尿（70.83%）。性别、年龄、体重指数（BMI）无显著差异。
本研究表明，健康、无症状的志愿者存在高比例的异常尿动力学发现，这表明在涉及尿动力学检查的研究中，无症状参与者并不是理想的对照组。
