Baraka A
Department of Anesthesiology, American University of Beirut, Lebanon.
Br J Anaesth. 1988 Oct;61(4):482-3. doi: 10.1093/bja/61.4.482.
Anaesthesia was induced with propofol 2.5 mg kg-1 followed by suxamethonium 1.5 mg kg-1 in six young healthy females undergoing laparoscopy. ECG was monitored continuously. In two unpremedicated patients, this was followed by severe sinus bradycardia, while no bradycardia was observed in the other four patients who were premedicated with atropine 0.6 mg i.m. These observations suggest that propofol-suxamethonium sequence may be followed by severe bradycardia in patients who have not received atropine. The bradycardia may be prevented by premedication with atropine. In contrast to thiopentone, propofol apparently lacks central vagolytic activity and may exert a central vagotonic effect which can exaggerate the muscarinic effects of suxamethonium.
对6名接受腹腔镜检查的年轻健康女性，先用2.5毫克/千克丙泊酚诱导麻醉，随后用1.5毫克/千克琥珀酰胆碱。持续监测心电图。在2名未进行术前用药的患者中，随后出现了严重的窦性心动过缓，而在另外4名术前肌内注射0.6毫克阿托品的患者中未观察到心动过缓。这些观察结果表明，在未接受阿托品的患者中，丙泊酚 - 琥珀酰胆碱给药顺序后可能会出现严重心动过缓。术前使用阿托品可预防心动过缓。与硫喷妥钠不同，丙泊酚显然缺乏中枢性抗迷走神经活性，可能会产生中枢性迷走神经兴奋作用，从而增强琥珀酰胆碱的毒蕈碱样作用。
