deKernion J B
Cancer Res. 1977 Aug;37(8 Pt 2):2771-4.
This paper is a summary of the clinical chemotherapy of metastatic or recurrent bladder carcinoma. Mitomycin C, doxorubicin, methotrexate, and 5-fluorouracil appear to have cytotoxic activity against bladder carcinoma when used as single agents, although the reported objective responses to each agent vary greatly. Cyclophosphamide in intermittent high i.v. doses produced an objective response in 4 of 10 patients treated by the author, and other reports suggest that this drug also may have activity against bladder cancer. cis-Dichlorodiammineplatinum is a new drug that also deserves further study.
本文是转移性或复发性膀胱癌临床化疗的综述。丝裂霉素C、阿霉素、甲氨蝶呤和5-氟尿嘧啶作为单一药物使用时，似乎对膀胱癌具有细胞毒性活性，尽管报道的每种药物的客观缓解率差异很大。作者对10例接受间歇性高剂量静脉注射环磷酰胺治疗的患者中的4例观察到客观缓解，其他报道表明该药物可能也对膀胱癌有活性。顺二氯二氨铂是一种新药，也值得进一步研究。
