Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Faculty of Biology, University of Freiburg, Freiburg, Germany.
Elife. 2020 Jul 8;9:e55602. doi: 10.7554/eLife.55602.
is a common colonizer of healthy skin and mucous membranes. At the same time, is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mφ) are critical for the coordinated defense against invading yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized skin infections persistently alter the resident Mφ subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with , showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mφ half-life, thereby limiting the duration of memory. In summary, resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.
是健康皮肤和黏膜的常见定植菌。同时，也是皮肤和软组织感染最常见的原因。皮肤巨噬细胞（Mφ）对于协调抵御入侵至关重要，但它们的寿命有限，会被骨髓来源的单核细胞替代。目前人们对局部皮肤感染是否会持续改变常驻 Mφ亚群组成以及对随后感染的抵抗力知之甚少。在一个严格的皮肤感染模型中，我们发现先前感染过的小鼠在二次感染时表现出更快的单核细胞募集、更强的细菌杀伤和更好的愈合能力。然而，皮肤感染会缩短 Mφ 的半衰期，从而限制了记忆的持续时间。总之，在葡萄球菌皮肤感染过程中，常驻皮肤 Mφ在局部被编程，独立于骨髓来源的单核细胞，导致对第二次感染的暂时性抵抗力增强。
