Carlile Simon R, Cahill Seán C, O'Brien Eóin C, Neto Nuno G B, Monaghan Michael G, McLoughlin Rachel M
Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Department of Mechanical, Manufacturing and Biomedical Engineering, Trinity College Dublin, Dublin, Ireland.
iScience. 2024 Oct 29;27(12):111284. doi: 10.1016/j.isci.2024.111284. eCollection 2024 Dec 20.
can induce trained immunity in murine macrophages offering protection against repeat exposure during skin infection. Here we demonstrate that exposure can result in non-specific trained immunity in humans and mice, enhancing macrophage responsiveness and bacterial clearance in a heterologous challenge. In humans, the enhanced macrophage responsiveness was accompanied by metabolic changes and histone modification. In mice, the enhanced responsiveness of macrophages occurred in conjunction with enhanced myelopoiesis. This report provides further insights on the host's response to the bacterium , indicating that exposure to this organism induces heterologous protection against subsequent gram-negative infection that is provided by macrophages. These findings support the hypothesis that has evolved to develop a mutualistic relationship with the host, imbuing the host with enhanced capacity to protect itself from attack by alternative pathogens, while potentially allowing to exert its dominance within its niche.
可在小鼠巨噬细胞中诱导训练有素的免疫，为皮肤感染期间的再次暴露提供保护。在此我们证明，暴露可导致人类和小鼠产生非特异性训练有素的免疫，增强巨噬细胞反应性并在异源攻击中促进细菌清除。在人类中，增强的巨噬细胞反应性伴随着代谢变化和组蛋白修饰。在小鼠中，巨噬细胞反应性的增强与骨髓生成增强同时发生。本报告进一步深入探讨了宿主对该细菌的反应，表明暴露于这种生物体可诱导巨噬细胞提供的针对后续革兰氏阴性感染的异源保护。这些发现支持了这样一种假说，即 已经进化到与宿主建立共生关系，赋予宿主增强的能力以保护自身免受其他病原体的攻击，同时可能允许 在其生态位内发挥主导作用。
