Department of Chemistry, Faculty of Science, Ain Shams University, Cairo 11566, Egypt.
Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Molecules. 2020 Jul 6;25(13):3076. doi: 10.3390/molecules25133076.
A simple potentiometric sensor is described for accurate, precise, and rapid determination of sulfite additives in beverages. The sensor is based on the use of cobalt phthalocyanine as a recognition material, dispersed in a plasticized poly(vinyl chloride) matrix membrane. -Nitrophenyl octyl ether (-NPOE) as a membrane solvent and tri-dodecylmethyl- ammonium chloride (TDMAC) as ion discriminators are used as membrane additives. Under the optimized conditions, sulfite ion is accurately and precisely measured under batch and flow injection modes of analysis. The sensor exhibits fast and linear response for 1.0 × 10-1.0 × 10 M (800-0.08 µg/mL) and 1.0 × 10-5.0 × 10 M (8000-4 µg/mL) sulfite with Nernstian slopes of -27.4 ± 0.3 and -23.7 ± 0.6 mV/concentration decade under static and hydrodynamic modes of operation, respectively. Results in good agreement with the standard iodometric method are obtained.Validation of the assay method is examined in details including precision, accuracy, bias, trueness, repeatability, reproducibility, and uncertainty and good performance characteristics of the method are obtained. The sensor response is stable over the pH range of 5 to 7 without any significant interference from most common anions. The advantages offered by the proposed sensor (i.e., wide range of assay, high accuracy and precision, low detection limit, reasonable selectivity, long term response stability, fast response, and long life span and absence of any sample pretreatment steps) suggest its use in the quality control/quality assurance routine tests in beverages industries, toxicological laboratories and by inspection authorities.
一种简单的电位传感器用于准确、精确和快速测定饮料中的亚硫酸盐添加剂。该传感器基于使用酞菁钴作为识别材料，分散在增塑聚氯乙烯基质膜中。-硝基苯辛基醚（-NPOE）作为膜溶剂和三辛基甲基-氯化铵（TDMAC）作为离子鉴别剂用作膜添加剂。在优化条件下，亚硫酸盐离子在批处理和流动注射分析模式下得到准确和精确的测量。传感器在静态和动态操作模式下分别对 1.0×10-1.0×10 M（800-0.08 µg/mL）和 1.0×10-5.0×10 M（8000-4 µg/mL）亚硫酸盐具有快速和线性响应，Nernst 斜率分别为-27.4±0.3 和-23.7±0.6 mV/浓度十年。与标准碘量法得到的结果非常吻合。详细检查了分析方法的验证，包括精密度、准确性、偏差、真实性、重复性、重现性和不确定性，并获得了该方法的良好性能特征。传感器在 pH 值为 5 至 7 的范围内响应稳定，不受大多数常见阴离子的显著干扰。该传感器提供了广泛的测定范围、高准确性和精密度、低检测限、合理的选择性、长期响应稳定性、快速响应和长寿命以及无需任何样品预处理步骤等优点，建议将其用于饮料行业、毒理学实验室和检验机构的质量控制/质量保证常规测试中。
