Department of Chemistry, Faculty of Science, Ain Shams University, Abbasia, Cairo, 11566, Egypt.
Mikrochim Acta. 2024 Nov 15;191(12):744. doi: 10.1007/s00604-024-06802-6.
A novel miniaturized, solid-contact potentiometric screen-printed electrode was developed for highly sensitive and selective determination of lidocaine anesthetic. The electrode integrated single-walled carbon nanotubes as a solid-contact material and a molecularly imprinted polymer as a recognition sensory material. The performance characteristics of the electrode were evaluated and optimized to display a Nernstian slope of 58.92 ± 0.98 mV/decade over a linear concentration range of 4.53 × 10 to 6.18 × 10 mol/l within < 6 s. The detection limit was 7.75 × 10 mol/l (18.16 ng/ml) of lidocaine. The use of the molecularly imprinted polymer significantly enhanced the selectivity of the electrode, and carbon nanotubes increased the sensitivity, accuracy, and potential stability. The electrode was successfully used for determining lidocaine in pharmaceutical preparations and human urine. The results favorably compared with data obtained by liquid chromatography-tandem mass spectrometry.
一种新型的微型、固态接触式丝网印刷电极被开发出来，用于高度灵敏和选择性地测定利多卡因麻醉剂。该电极集成了单壁碳纳米管作为固态接触材料和分子印迹聚合物作为识别传感材料。对电极的性能特征进行了评估和优化，使其在 4.53×10 到 6.18×10 mol/l 的线性浓度范围内呈现出 58.92±0.98 mV/decade 的 Nernst 斜率，响应时间小于 6 秒。检测限为 7.75×10 mol/l（18.16ng/ml）的利多卡因。分子印迹聚合物的使用显著提高了电极的选择性，而碳纳米管则提高了灵敏度、准确性和潜在稳定性。该电极成功地用于测定药物制剂和人尿中的利多卡因。结果与液相色谱-串联质谱法获得的数据吻合良好。
