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优化鞣花酸-果胶钙漂浮珠对吲哚美辛诱导的大鼠胃损伤的胃保护作用。

Optimized Ellagic Acid-Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.

机构信息

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Advanced Drug Delivery Research Group, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

出版信息

Biomolecules. 2020 Jul 6;10(7):1006. doi: 10.3390/biom10071006.

DOI:10.3390/biom10071006
PMID:32640741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7408148/
Abstract

A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1-3 w/v %), EA concentration (X2, 1-3 w/v %) and the dropping time (X3, 10-30 min). The factorial design proposed eight formulations. The optimized EA-Ca pectinate formulation was evaluated for the gastric ulcer index and the oxidative stress parameter determination of gastric mucosa. The results indicated that the optimum EA-Ca pectinate formula significantly improved the gastric ulcer index in comparison with raw EA. The protective effect of the optimized EA-Ca pectinate formula was further indicated by the histopathological features of the stomach. The results of the study indicate that an EA formulation in the form of Ca pectinate beads would be effective for protection against gastric ulcers because of Nonsteroidal anti-inflammatory drugs (NSAID) administration.

摘要

消化性溃疡是一种导致黏膜缺损到达黏膜下层的消化道损伤。本工作旨在优化和最大限度地提高鞣花酸（EA）在海藻酸钠漂浮珠中的负载量，以实现 24 小时的最大释放。选择了三个因素：海藻酸钠浓度（X1，1-3 w/v%）、EA 浓度（X2，1-3 w/v%）和滴注时间（X3，10-30 分钟）。该实验设计提出了八种配方。对优化的 EA-海藻酸钠配方进行了胃溃疡指数和胃黏膜氧化应激参数的测定。结果表明，与原 EA 相比，优化的 EA-海藻酸钠配方能显著改善胃溃疡指数。优化的 EA-海藻酸钠配方的保护作用还通过胃的组织病理学特征得到进一步证实。研究结果表明，EA 海藻酸钠珠制剂形式将对非甾体抗炎药（NSAID）引起的胃溃疡有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/837cf6e78817/biomolecules-10-01006-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/4c6aa3695257/biomolecules-10-01006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/89115e2a25f8/biomolecules-10-01006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/79270e5db290/biomolecules-10-01006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/27d9d8cc75c3/biomolecules-10-01006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/b3c985907d01/biomolecules-10-01006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/0d23fec2643b/biomolecules-10-01006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/270493553465/biomolecules-10-01006-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/e9a27e2d4368/biomolecules-10-01006-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/cb57e116321d/biomolecules-10-01006-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/837cf6e78817/biomolecules-10-01006-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/4c6aa3695257/biomolecules-10-01006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/89115e2a25f8/biomolecules-10-01006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/79270e5db290/biomolecules-10-01006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/27d9d8cc75c3/biomolecules-10-01006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/b3c985907d01/biomolecules-10-01006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/0d23fec2643b/biomolecules-10-01006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/270493553465/biomolecules-10-01006-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/e9a27e2d4368/biomolecules-10-01006-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/cb57e116321d/biomolecules-10-01006-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136e/7408148/837cf6e78817/biomolecules-10-01006-g010.jpg

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2
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Pharmaceutics. 2024 Jan 29;16(2):192. doi: 10.3390/pharmaceutics16020192.
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本文引用的文献

1
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J Pharm Sci. 2020 Jul;109(7):2145-2155. doi: 10.1016/j.xphs.2020.03.009. Epub 2020 Mar 17.
2
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3
New developments in diagnosis, risk assessment and management in systemic amyloidosis.
Polymeric Excipients in the Technology of Floating Drug Delivery Systems.
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Pharmaceutics. 2022 Dec 12;14(12):2779. doi: 10.3390/pharmaceutics14122779.
4
Bio-Based Formulations for Sustainable Applications in Agri-Food-Pharma.生物基配方在农食医药领域的可持续应用。
Biomolecules. 2021 May 20;11(5):768. doi: 10.3390/biom11050768.
5
Pretreatment with XY18 Relieves Gastric Injury Induced by HCl/Ethanol in Mice via Antioxidant and Anti-Inflammatory Mechanisms.预处理 XY18 通过抗氧化和抗炎机制缓解 HCl/乙醇诱导的小鼠胃损伤。
Drug Des Devel Ther. 2020 Dec 30;14:5721-5734. doi: 10.2147/DDDT.S280429. eCollection 2020.
系统性淀粉样变的诊断、风险评估和治疗的新进展。
Blood Rev. 2020 Mar;40:100636. doi: 10.1016/j.blre.2019.100636. Epub 2019 Nov 2.
4
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5
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6
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7
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8
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9
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10
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ACS Omega. 2017 Nov 30;2(11):7991-7995. doi: 10.1021/acsomega.7b01109. Epub 2017 Nov 16.