Tran Phuong H L, Tran Thao T D
Deakin University, Geelong Australia, School of Medicine, Melbourne, Vic, Australia
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
Anticancer Agents Med Chem. 2020;20(16):1874-1882. doi: 10.2174/1871520620666200708103845.
Although curcumin has been demonstrated to be beneficial in treating various diseases, its low solubility, chemical stability and bioavailability limit its application, especially in cancer therapy.
Solid dispersions have been utilized in the last few decades to improve the bioavailability and stability of curcumin.
However, there is a lack of summaries and classifications of the methods for preparing curcumin with this technology. The current review aims to overview the strategies used to develop solid dispersions containing curcumin for improving drug delivery. The classification of techniques for creating solid dispersions for curcumin was summarized, including systems for protecting curcumin degradation despite its chemical stability. The applications of advanced nanotechnologies in recent studies of solid dispersions were also discussed to explain the roles of nanoparticles in formulations.
This overview of recent developments in formulating solid dispersions for improving curcumin bioavailability will contribute to future studies of curcumin for clinical development.
尽管姜黄素已被证明对治疗多种疾病有益，但其低溶解度、化学稳定性和生物利用度限制了其应用，尤其是在癌症治疗中。
在过去几十年中，固体分散体已被用于提高姜黄素的生物利用度和稳定性。
然而，缺乏用该技术制备姜黄素方法的总结和分类。当前综述旨在概述用于开发含姜黄素固体分散体以改善药物递送的策略。总结了用于制备姜黄素固体分散体的技术分类，包括尽管姜黄素化学稳定性较差但仍能保护其降解的体系。还讨论了先进纳米技术在近期固体分散体研究中的应用，以解释纳米颗粒在制剂中的作用。
对用于提高姜黄素生物利用度的固体分散体制备最新进展的概述将有助于姜黄素临床开发的未来研究。
