Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University (Jamia Hamdard), New Delhi-62, India.
Crit Rev Ther Drug Carrier Syst. 2010;27(4):279-312. doi: 10.1615/critrevtherdrugcarriersyst.v27.i4.10.
Turmeric, the source of the polyphenolic active compound curcumin (diferuloylmethane), has been used extensively in traditional medicine since ancient times as a household remedy against various diseases, including hepatic disorders, cough, sinusitis, rheumatism, and biliary disorders. In the past few decades, a number of studies have been done on curcumin showing its potential role in treating inflammatory disorders, cardiovascular disease, cancer, AIDS, and neurological disorders. However, the main drawback associated with curcumin is its poor aqueous solubility and stability in gastrointestinal fluids, which leads to poor bioavailability. Multifarious novel drug-delivery approaches, including microemulsions, nanoemulsions, liposomes, solid lipid nanoparticles, microspheres, solid dispersion, polymeric nanoparticles, and self-microemulsifying drug-delivery systems have been used to enhance the bioavailability and tissue-targeting ability of curcumin. These attempts have revealed promising results for enhanced bioavailability and targeting to disease such as cancer, but more extensive research on tissue-targeting and stability-related issues is needed. Tissue targeting and enhanced bioavailability of curcumin using novel drug-delivery methods with minimum side effects will in the near future bring this promising natural product to the forefront of therapy for the treatment of human diseases such as cancer and cardiovascular ailments. We provide a detailed analysis of prominent research in the field of curcumin drug delivery with special emphasis on bioavailability-enhancement approaches and novel drug-delivery system approaches.
姜黄，多酚类活性化合物姜黄素（二芳基甲烷）的来源，自古以来就在传统医学中被广泛用作家庭疗法，用于治疗各种疾病，包括肝脏疾病、咳嗽、鼻窦炎、风湿和胆道疾病。在过去的几十年中，已经有许多关于姜黄素的研究表明它在治疗炎症性疾病、心血管疾病、癌症、艾滋病和神经退行性疾病方面具有潜在作用。然而，姜黄素的主要缺点是其在胃肠道液中的水溶性和稳定性差，导致生物利用度差。各种新的药物输送方法，包括微乳液、纳米乳液、脂质体、固体脂质纳米粒、微球、固体分散体、聚合物纳米粒和自微乳药物输送系统，已被用于提高姜黄素的生物利用度和组织靶向能力。这些尝试已经为增强生物利用度和针对癌症等疾病的靶向性提供了有希望的结果，但需要对组织靶向和与稳定性相关的问题进行更广泛的研究。使用新的药物输送方法，通过最小化副作用来实现姜黄素的组织靶向和增强生物利用度，将在不久的将来使这种有前途的天然产物成为治疗癌症和心血管疾病等人类疾病的治疗的前沿。我们对姜黄素药物输送领域的突出研究进行了详细分析，特别强调了生物利用度增强方法和新型药物输送系统方法。
