Department of Family Medicine, Brown University Warren Alpert Medical School, Providence, Rhode Island02903, USA.
Providence Community Health Centers, Providence, Rhode Island02905, USA.
Epidemiol Infect. 2020 Jul 9;148:e140. doi: 10.1017/S0950268820001569.
Coronavirus disease 2019 (COVID-19) has resulted in a global pandemic, and there is limited data on effective therapies. Bacillus Calmette-Guérin (BCG) vaccine, a live-attenuated strain derived from an isolate of Mycobacterium bovis and originally designed to prevent tuberculosis, has shown some efficacy against infection with unrelated pathogens. In this study, we reviewed 120 consecutive adult patients (≥18 years old) with COVID-19 at a major federally qualified health centre in Rhode Island, United States from 19 March to 29 April 2020. Median age was 39.5 years (interquartile range, 27.0-50.0), 30% were male and 87.5% were Latino/Hispanics. Eighty-two (68.3%) patients had BCG vaccination. Individuals with BCG vaccination were less likely to require hospital admission during the disease course (3.7% vs. 15.8%, P = 0.019). This association remained unchanged after adjusting for demographics and comorbidities (P = 0.017) using multivariate regression analysis. The finding from our study suggests the potential of BCG in preventing more severe COVID-19.
2019 年冠状病毒病（COVID-19）已在全球范围内大流行，目前针对有效的治疗方法的数据有限。卡介苗（BCG）疫苗是一种从牛分枝杆菌分离株衍生而来的减毒活疫苗，最初用于预防结核病，它对预防不相关的病原体感染显示出一定的效果。在这项研究中，我们回顾了 2020 年 3 月 19 日至 4 月 29 日在美国罗德岛州一家主要的联邦合格健康中心治疗的 120 例连续的成年 COVID-19 患者（≥18 岁）。中位年龄为 39.5 岁（四分位间距，27.0-50.0），30%为男性，87.5%为拉丁裔/西班牙裔。82 例（68.3%）患者接种了 BCG 疫苗。在疾病过程中，接种 BCG 疫苗的患者更不可能需要住院治疗（3.7%比 15.8%，P = 0.019）。使用多元回归分析调整人口统计学和合并症后，这种相关性仍然不变（P = 0.017）。我们的研究结果表明 BCG 可能具有预防更严重 COVID-19 的潜力。
