Department of Psychology, University of Alabama at Birmingham, Birmingham, USA.
Mol Pain. 2017 Jan-Dec;13:1744806917724559. doi: 10.1177/1744806917724559.
Chronic pain is a significant problem worldwide and is the most common disability in the United States. It is well known that the immune system plays a critical role in the development and maintenance of many chronic pain conditions. The involvement of the immune system can be through the release of autoantibodies, in the case of rheumatoid arthritis, or via cytokines, chemokines, and other inflammatory mediators (i.e. substance P, histamine, bradykinin, tumor necrosis factor, interleukins, and prostaglandins). Immune cells, such as T cells, B cells and their antibodies, and microglia are clearly key players in immune-related pain. The purpose of this review is to briefly discuss the immune system involvement in pain and to outline how it relates to rheumatoid arthritis, osteoarthritis, fibromyalgia, complex regional pain syndrome, multiple sclerosis, and diabetic neuropathy. The immune system plays a major role in many debilitating chronic pain conditions and we believe that animal models of disease and their treatments should be more directly focused on these interactions.
慢性疼痛是一个全球性的重大问题，也是美国最常见的残疾。众所周知，免疫系统在许多慢性疼痛疾病的发展和维持中起着关键作用。免疫系统的参与可以通过自身抗体的释放来实现，例如在类风湿关节炎中，或者通过细胞因子、趋化因子和其他炎症介质（即 P 物质、组胺、缓激肽、肿瘤坏死因子、白细胞介素和前列腺素）。免疫细胞，如 T 细胞、B 细胞及其抗体和小胶质细胞，显然是免疫相关疼痛的关键参与者。本综述的目的是简要讨论免疫系统在疼痛中的作用，并概述其与类风湿关节炎、骨关节炎、纤维肌痛、复杂性区域疼痛综合征、多发性硬化症和糖尿病性神经病的关系。免疫系统在许多使人衰弱的慢性疼痛疾病中起着重要作用，我们认为疾病的动物模型及其治疗方法应该更直接地关注这些相互作用。
