Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
J Am Med Dir Assoc. 2020 Dec;21(12):2017.e1-2017.e9. doi: 10.1016/j.jamda.2020.05.005. Epub 2020 Jul 5.
This study aimed to characterize the biomarker profile of sarcopenic vs nonsarcopenic men and women, using the current European Working Group on Sarcopenia in Older People (EWGSOP2) definition in the UK Biobank study.
Cross-sectional study.
A total of 396,707 (68.8% women, age 38 to 73) participants from UK Biobank.
Thirty-three biomarkers, standardized to sex-specific z-scores, were included in the analysis. Associations between these biomarkers and sarcopenia, defined using EWGSOP2 criteria, were examined using multiple linear regression.
Higher concentrations of rheumatoid factor, C-reactive protein, cystatin C, sex hormone-binding globulin, gamma-glutamyltransferase, alkaline phosphatase, and total protein, as well as lower concentrations of insulin-like growth factor-1, albumin, creatinine, sodium, and systolic blood pressure, were associated with sarcopenia in both men and women. However, some of the associations differed by sex. Sarcopenia was associated with higher concentrations of phosphate, lipoprotein A, and lower of diastolic blood pressure, HbA1c, urea, glucose, total bilirubin, and testosterone in women only, and with higher concentrations of high-density lipoprotein, aspartate aminotransferase, and direct bilirubin and lower values of apolipoprotein A, vitamin D, and apolipoprotein B in men only.
Several biomarkers were associated with sarcopenia in men and women using the new EWGSOP2 statement. However, some of these associations and their magnitude differed between men and women. Considering the EWGSOP2 updated its statement on the definition of sarcopenia in 2019, this study enables us to update the study of the biomarkers profile of people with sarcopenia.
本研究旨在使用英国生物库研究中当前的欧洲老年人肌少症工作组（EWGSOP2）定义，描述肌少症与非肌少症男性和女性的生物标志物特征。
横断面研究。
来自英国生物库的共 396707 名参与者（68.8%为女性，年龄 38 至 73 岁）。
分析中纳入了 33 种生物标志物，这些标志物经过性别特异性 z 分数标准化。使用多元线性回归检查这些生物标志物与使用 EWGSOP2 标准定义的肌少症之间的关联。
类风湿因子、C 反应蛋白、胱抑素 C、性激素结合球蛋白、γ-谷氨酰转移酶、碱性磷酸酶和总蛋白浓度较高，以及胰岛素样生长因子-1、白蛋白、肌酐、钠和收缩压浓度较低与男女肌少症均相关。然而，一些关联因性别而异。肌少症与女性磷酸盐、脂蛋白 A 浓度较高和舒张压、HbA1c、尿素、葡萄糖、总胆红素和睾酮较低相关，仅与高密度脂蛋白、天门冬氨酸氨基转移酶和直接胆红素浓度较高和载脂蛋白 A、维生素 D 和载脂蛋白 B 浓度较低相关。
使用新的 EWGSOP2 声明，一些生物标志物与男性和女性的肌少症相关。然而，这些关联及其程度在男性和女性之间存在差异。考虑到 EWGSOP2 在 2019 年更新了肌少症的定义，本研究使我们能够更新肌少症患者的生物标志物特征研究。
