Department of General Internal Medicine, Tenri Hospital, Japan.
Department of Health Care, Tenri Health Care University, Japan.
Intern Med. 2020 Nov 1;59(21):2789-2795. doi: 10.2169/internalmedicine.4964-20. Epub 2020 Jul 7.
Lupus aortitis is a rare and potentially life-threatening disorder. Previous studies have reported the utility of high-dose systemic glucocorticoids or surgery as the treatment, although there have been no related controlled trials. We herein report a 49-year-old woman with a 35-year history of systemic lupus erythematosus who was diagnosed with aortitis. Her symptoms and laboratory and imaging abnormalities rapidly resolved upon the administration of moderate-dose glucocorticoids. We subsequently performed a literature review of similar cases to identify the appropriate treatment and discuss these cases. A study of further cases will be needed to identify the characteristics of patients who would benefit from moderate-dose glucocorticoid therapy.
狼疮性主动脉炎是一种罕见且可能危及生命的疾病。既往研究报道了大剂量全身糖皮质激素或手术治疗的效果，尽管尚无相关对照试验。我们在此报告 1 例 49 岁女性，系统性红斑狼疮病史 35 年，诊断为主动脉炎。给予中等剂量糖皮质激素后，其症状以及实验室和影像学异常迅速缓解。随后我们对类似病例进行了文献复习，以确定适当的治疗方法并讨论这些病例。需要进一步研究更多病例，以明确从中等剂量糖皮质激素治疗中获益的患者特征。
