一种在人体脂肪组织中引发产热的新方法。
A new way to ignite thermogenesis in human adipose tissue.
机构信息
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
出版信息
Nat Rev Endocrinol. 2020 Sep;16(9):475-476. doi: 10.1038/s41574-020-0390-4.
Abstract
Thermogenic adipose tissue is a metabolic sink for excess fuel and is a promising target for the treatment of obesity and type 2 diabetes mellitus. However, hurdles exist in activating thermogenic adipose tissue in humans. A new study developed a drug screening platform utilizing human beige adipose tissue and identified non-canonical activators.
摘要
产热脂肪组织是多余燃料的代谢汇，是治疗肥胖症和 2 型糖尿病的有前途的靶点。然而，在人类中激活产热脂肪组织存在障碍。一项新的研究利用人类米色脂肪组织开发了一种药物筛选平台，并鉴定了非经典的激活剂。
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