Worldwide Medicinal Chemistry, Pfizer, Inc., 620 Memorial Dr., Cambridge, MA 02139, USA.
Worldwide Medicinal Chemistry, Pfizer, Inc., 620 Memorial Dr., Cambridge, MA 02139, USA.
Bioorg Med Chem Lett. 2014 Jan 15;24(2):425-9. doi: 10.1016/j.bmcl.2013.12.016. Epub 2013 Dec 10.
There is a renewed interest in the role of adipose tissue in energy utilization and thermogenesis and its potential application in the treatment of metabolic disorders such as obesity and diabetes. The last few years have seen the identification of brown adipose tissue capable of metabolic activation in adult humans, the possibility of recruiting 'beige' adipocytes to increase energy expenditure, and the implication of molecules such as FGF21 and irisin in inducing increases in energy expenditure in adipose tissue. The translation of these findings into human trials to deliver safe, efficacious medicines remains a challenge.
人们对脂肪组织在能量利用和产热中的作用重新产生了兴趣，以及它在治疗肥胖症和糖尿病等代谢紊乱方面的潜在应用。在过去的几年中，人们已经确定了成年人体内能够进行代谢激活的棕色脂肪组织，以及招募“米色”脂肪细胞来增加能量消耗的可能性，并且发现了 FGF21 和鸢尾素等分子在诱导脂肪组织能量消耗增加方面的作用。将这些发现转化为人体试验以提供安全、有效的药物仍然是一个挑战。
