Gao Yunxiao, Liu Yiwen, Han Xue, Zhou Fang, Guo Jielong, Huang Weidong, Zhan Jicheng, You Yilin
Beijing Key Laboratory of Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
College of Health Solutions, Arizona State University, Phoenix, AZ, United States.
Front Nutr. 2022 Oct 28;9:896021. doi: 10.3389/fnut.2022.896021. eCollection 2022.
Coconut oil (CO) and its main ingredients, medium-chain fatty acids (MCFA), present many benefits. Whether MCFA and CO play an equally valuable role in anti-obesity remains unclear. This study compared the anti-obesity effects of CO and MCFA [octanoic acid (C8:0) and decanoic acid (C10:0)] to gain insight into the underlying mechanism. Male C57BL/6J mice were fed either a low-fat diet (LFD) or high-fat diet (100% HFD) replaced with 2.5% MCFA (97.5% HFD + 2.5% MCFA) or 5% CO (95% HFD + 5% CO) for 17 weeks. CO and MCFA ameliorated the HFD-induced abnormal body and adipose depot weights, insulin sensitivity, and energy expenditure (EE), which was associated with brown adipose tissue (BAT) thermogenesis. Furthermore, CO enhanced the expression of thermogenesis markers in BAT, which was consistent with increased BAT activity. CO showed a better effect than MCFA in activating BAT to increase thermogenesis and energy metabolism to combat obesity, which may be attributed to the cooperation of MCFA and other substances in CO. This work provides evidence for the anti-obesity effects of CO, which could be a better alternative to lard in daily diet, rather than pure MCFA.
椰子油（CO）及其主要成分中链脂肪酸（MCFA）具有诸多益处。MCFA和CO在抗肥胖方面是否发挥同等重要的作用仍不明确。本研究比较了CO和MCFA[辛酸（C8:0）和癸酸（C10:0）]的抗肥胖作用，以深入了解其潜在机制。雄性C57BL/6J小鼠分别喂食低脂饮食（LFD）或高脂饮食（100%HFD），其中高脂饮食用2.5%MCFA（97.5%HFD + 2.5%MCFA）或5%CO（95%HFD + 5%CO）替代，持续17周。CO和MCFA改善了高脂饮食诱导的异常体重、脂肪储存重量、胰岛素敏感性和能量消耗（EE），这与棕色脂肪组织（BAT）产热有关。此外，CO增强了BAT中产热标志物的表达，这与BAT活性增加一致。在激活BAT以增加产热和能量代谢以对抗肥胖方面，CO比MCFA表现出更好的效果，这可能归因于CO中MCFA与其他物质的协同作用。这项工作为CO的抗肥胖作用提供了证据，在日常饮食中，CO可能是比猪油更好的替代品，而不是纯MCFA。
