由双响应性聚合物纳米颗粒递送的姜黄素铂配合物基于增强的抗转移活性提高了化疗疗效并减少了副作用。

Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects.

作者信息

Chen Yan, Chen Chen, Zhang Xiaojuan, He Chuanchuan, Zhao Pengxuan, Li Minsi, Fan Ting, Yan Ruicong, Lu Yao, Lee Robert J, Khan Muhammad Waseem, Sarfraz Muhammad, Ma Xiang, Yang Tan, Xiang Guangya

机构信息

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

College of Pharmacy, the Ohio State University, Columbus, OH 43210, USA.

出版信息

Acta Pharm Sin B. 2020 Jun;10(6):1106-1121. doi: 10.1016/j.apsb.2019.10.011. Epub 2019 Nov 1.

Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt-CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects. Pt-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ∼100 nm. The nanoparticles showed increased anti-cancer effects both and . In addition, Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2, resulting in enhanced anti-metastatic activity. Furthermore, reduced side effects were also observed. In conclusion, Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.