Department of Child and Adolescent Psychiatry, Programa AMI-TEA, Servicio de Psiquiatría del Niño y del Adolescente, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, School of Medicine, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Universidad Complutense, C/ Ibiza, 43, 28009, Madrid, Spain.
Psychiatry/Medical Specialities Department, Faculty of Medicine, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, University of Alcalá, Madrid, Spain.
J Autism Dev Disord. 2020 Aug;50(8):3046-3059. doi: 10.1007/s10803-020-04408-4.
Social cognition impairment is a core shared phenotype in both schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD). This study compares social cognition performance through four different instruments in a sample of 147 individuals with ASD or SSD and in healthy controls. We found that both clinical groups perform similarly to each other and worse than healthy controls in all social cognition tasks. Only performance on the Movie for the Assessment of Social Cognition (MASC) test was independent of age and intelligence. Proportionately, individuals in the control group made significantly more overmentalization errors than both patients group did and made fewer undermentalization errors than patients with SSD did. AUC analyses showed that the MASC was the instrument that best discriminated between the clinical and control groups. Multivariate analysis showed negative symptom severity as a potential mediator of the association between social cognition deficit and poor global functioning.
社会认知障碍是精神分裂谱系障碍（SSD）和自闭症谱系障碍（ASD）的核心共有表型。本研究通过四种不同的工具在 ASD 或 SSD 患者样本中比较社会认知表现 147 名个体和健康对照组。我们发现，两个临床组在所有社会认知任务中的表现都彼此相似，且都不如健康对照组。只有电影评估社会认知（MASC）测试的表现与年龄和智力无关。比例上，对照组的个体比两个患者组做出更多的过度心理化错误，比 SSD 患者组做出更少的过低心理化错误。AUC 分析表明，MASC 是区分临床组和对照组的最佳工具。多变量分析显示，阴性症状严重程度是社会认知缺陷与整体功能不良之间关联的潜在中介。
