Martinez Gilles, Alexandre Charlotte, Mam-Lam-Fook Célia, Bendjemaa Narjes, Gaillard Raphaël, Garel Patricia, Dziobek Isabel, Amado Isabelle, Krebs Marie-Odile
INSERM, Laboratoire Physiopathologie des maladies Psychiatriques, Centre de psychiatrie et neurosciences, U894 Paris, France; Université Paris-Descartes, Sorbonne Paris-Cité, Faculté de Médecine Paris-Descartes, Paris, France; Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France; Institut de psychiatrie (GDR 3557), France.
Université de Montréal, CHU Ste-Justine, Montréal, Canada.
Schizophr Res. 2017 Jul;185:161-166. doi: 10.1016/j.schres.2017.01.012. Epub 2017 Jan 11.
Schizophrenic (SCZ) and autism (ASD) spectrum disorders share several features including social cognition impairments. In SCZ, the link between symptomatic dimensions and social cognition deficits remains unclear. The Movie for the Assessment of Social Cognition (MASC) test, available in several languages including English, investigates mental state attribution capabilities in complex interpersonal situations. After its translation into French, we used MASC to direct compare social cognition in 36 young participants with SCZ to 19 with ASD and 20 healthy controls (HC) matched for gender, age (18-25y.o.) and level of education. The MASC discriminated each group from the others, patients with SCZ exhibiting difficulties compared to ASD (MASC total score 28.1 (4) and 24.2 (6.6), respectively; p<.001). In the whole sample, MASC scores were inversely correlated with autistic traits, evaluated by autism quotient, and with disorganization symptoms. Finally, in SCZ, over-mentalizing difficulties were correlated with age at disease onset. Our results demonstrate the validity of the French version of the MASC and bring direct evidence supporting the hypothesis of a phenotypic continuum between autism and schizophrenia.
精神分裂症（SCZ）和自闭症谱系障碍（ASD）有若干共同特征，包括社会认知障碍。在精神分裂症中，症状维度与社会认知缺陷之间的联系尚不清楚。社会认知评估电影（MASC）测试有包括英语在内的多种语言版本，可用于研究复杂人际情境中的心理状态归因能力。在将其翻译成法语后，我们使用MASC直接比较了36名患有精神分裂症的年轻参与者、19名患有自闭症谱系障碍的参与者以及20名在性别、年龄（18 - 25岁）和教育水平方面匹配的健康对照者（HC）的社会认知。MASC能够区分不同组，与自闭症谱系障碍患者相比，精神分裂症患者表现出困难（MASC总分分别为28.1（4）和24.2（6.6）；p <.001）。在整个样本中，MASC得分与通过自闭症商数评估的自闭症特征以及紊乱症状呈负相关。最后，在精神分裂症患者中，过度心理化困难与疾病发病年龄相关。我们的结果证明了法语版MASC的有效性，并提供了直接证据支持自闭症和精神分裂症之间存在表型连续体的假设。
