Altaf S, Haider A, Naz S, Ul-Hamid A, Haider J, Imran M, Shahzadi A, Naz M, Ajaz H, Ikram M
Department of Chemistry, University of Engineering and Technology, Lahore, 54000, Pakistan.
Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, Punjab, 54000, Pakistan.
Nanoscale Res Lett. 2020 Jul 8;15(1):144. doi: 10.1186/s11671-020-03375-0.
The present research is a comparative study that reports an economical and accessible method to synthesize niobium (Nb) and Tantalum (Ta) selenides and tellurides with useful application in the removal of pollutants in textile, paper, and dyeing industries as well as in medical field. In this study, solid-state process was used to generate nanocomposites and various characterization techniques were employed to compare two groups of materials under investigation. Structure, morphology, elemental constitution, and functional groups of synthesized materials were analyzed with XRD, FESEM coupled with EDS, FTIR, and Raman spectroscopy, respectively. HR-TEM images displayed nanoscale particles with tetragonal and monoclinic crystal structures. The optical properties were evaluated in terms of cut-off wavelength and optical band gap using UV-visible spectroscopy. A comparative behavior of both groups of compounds was assessed with regards to their catalytic and microcidal properties. Extracted nanocomposites when used as catalysts, though isomorphs of each other, showed markedly different behavior in catalytic degradation of MB dye in the presence of NaBH that was employed as a reducing agent. This peculiar deviation might be attributed to slight structural differences between them. Escherichia coli and Staphylococcus aureus (G -ve and + ve bacteria, respectively) were designated as model strains for in vitro antibacterial tests of both clusters by employing disk diffusion method. Superior antibacterial efficacy was observed for telluride system (significant inhibition zones of 26-35 mm) compared with selenide system (diameter of inhibition zone ranged from 0.8 mm to 1.9 mm). In addition, molecular docking study was undertaken to ascertain the binding interaction pattern between NPs and active sites in targeted cell protein. The findings were in agreement with antimicrobial test results suggesting NbTe to be the best inhibitor against FabH and FabI enzymes.
本研究是一项比较研究，报告了一种经济且可行的方法来合成铌（Nb）和钽（Ta）的硒化物及碲化物，这些化合物在纺织、造纸和印染工业以及医学领域的污染物去除方面具有实用价值。在本研究中，采用固态法制备纳米复合材料，并运用各种表征技术对两组研究材料进行比较。分别使用X射线衍射（XRD）、场发射扫描电子显微镜（FESEM）结合能谱仪（EDS）、傅里叶变换红外光谱（FTIR）和拉曼光谱对合成材料的结构、形态、元素组成和官能团进行分析。高分辨率透射电子显微镜（HR-TEM）图像显示出具有四方和单斜晶体结构的纳米级颗粒。利用紫外-可见光谱，根据截止波长和光学带隙对光学性质进行评估。评估了两组化合物在催化和杀菌性能方面的比较行为。提取的纳米复合材料用作催化剂时，尽管彼此为同构体，但在以硼氢化钠（NaBH）作为还原剂存在的情况下，对亚甲基蓝（MB）染料的催化降解表现出明显不同的行为。这种特殊的偏差可能归因于它们之间细微的结构差异。通过采用纸片扩散法，将大肠杆菌和金黄色葡萄球菌（分别为革兰氏阴性菌和革兰氏阳性菌）指定为两组体外抗菌测试的模型菌株。与硒化物体系（抑菌圈直径范围为0.8毫米至1.9毫米）相比，碲化物体系观察到了更好的抗菌效果（显著抑菌圈为26至35毫米）。此外，进行了分子对接研究，以确定纳米颗粒与靶向细胞蛋白活性位点之间的结合相互作用模式。研究结果与抗菌测试结果一致，表明NbTe是针对FabH和FabI酶的最佳抑制剂。
