Berseth C L, Go V L
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota 55905.
J Pediatr Gastroenterol Nutr. 1988 Nov-Dec;7(6):889-93. doi: 10.1097/00005176-198811000-00017.
Previous studies have shown that orally administered epidermal growth factor (EGF) enhances neonatal intestinal growth and that it may be absorbed in the intestine and bound by other organs. This study investigated whether the ingestion of EGF would be associated with growth of nonintestinal organs. In short-term studies, 87 newborn rat pups were fed artificial formula containing various concentrations of EGF for 39 h. In long-term studies, suckling newborn pups were fed EGF or an equal volume of distilled water for 5 days. The pups fed formula containing EGF for 39 h had a significant increase in hepatic incorporation of [3H]thymidine into DNA compared with pups not fed EGF. By 5 days of age, 13 pups fed EGF had heavier livers that contained more DNA and RNA compared with 14 control pups. Moreover, EGF-fed pups had heavier hearts and kidneys than pups fed no EGF. These data suggested that ingestion of EGF is associated with the growth of nonintestinal organs.
先前的研究表明，口服表皮生长因子（EGF）可促进新生动物肠道生长，且它可能在肠道被吸收并被其他器官结合。本研究调查了摄入EGF是否与非肠道器官的生长有关。在短期研究中，87只新生大鼠幼崽被喂食含有不同浓度EGF的人工配方奶39小时。在长期研究中，哺乳的新生幼崽被喂食EGF或等体积的蒸馏水，持续5天。与未喂食EGF的幼崽相比，喂食含EGF配方奶39小时的幼崽肝脏中[3H]胸腺嘧啶掺入DNA的量显著增加。到5日龄时，与14只对照幼崽相比，13只喂食EGF的幼崽肝脏更重，且含有更多的DNA和RNA。此外，喂食EGF的幼崽心脏和肾脏也比未喂食EGF的幼崽更重。这些数据表明，摄入EGF与非肠道器官的生长有关。
