Berseth C L
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota 55905.
Am J Physiol. 1987 Nov;253(5 Pt 1):G662-5. doi: 10.1152/ajpgi.1987.253.5.G662.
Breast milk has been shown to enhance neonatal intestinal growth. Because epidermal growth factor (EGF) is present in the milk of various mammalian species, the hypothesis was tested that EGF in rodent milk mediates, in part, the breast milk-enhanced intestinal growth in neonatal rat. Fifty-eight rat pups fed artificial formula that contained 1.2, 3.0, and 6.0 micrograms/ml EGF for 39 h had greater incorporation of [3H]thymidine into DNA and DNA content of intestine than 29 pups fed unsupplemented formula. Pups fed EGF for 5 days had significantly greater body weight, intestinal weight, length, and DNA content than control pups. Conversely, pups fed pooled rat milk containing rabbit-derived antibody to EGF for 39 h had intestines of lower weight that contained less DNA than animals fed rat milk containing normal rabbit serum. EGF appears to mediate in part, breast milk-enhanced neonatal intestinal growth.
母乳已被证明能促进新生儿肠道生长。由于表皮生长因子（EGF）存在于各种哺乳动物的乳汁中，因此对啮齿动物乳汁中的EGF部分介导新生大鼠母乳增强肠道生长这一假说进行了验证。58只幼鼠喂食含1.2、3.0和6.0微克/毫升EGF的人工配方奶39小时，其肠道中[3H]胸腺嘧啶核苷掺入DNA以及DNA含量均高于29只喂食未添加配方奶的幼鼠。喂食EGF 5天的幼鼠体重、肠道重量、长度及DNA含量均显著高于对照幼鼠。相反，喂食含兔源抗EGF抗体的混合大鼠乳汁39小时的幼鼠，其肠道重量低于喂食含正常兔血清大鼠乳汁的动物，且DNA含量也较低。EGF似乎部分介导了母乳增强的新生儿肠道生长。
