Warmold A, van den Wall Bake L, Peeters A J, van der Ark A, Daha M R, Cats A, van Es L A
Department of Nephrology, University Hospital, Leiden, The Netherlands.
J Rheumatol. 1988 Sep;15(9):1410-4.
Immunoglobulin synthesis by peripheral blood lymphocytes and serum IgA subclasses were investigated in patients with ankylosing spondylitis (AS) with and without accompanying microscopic hematuria, and HLA-B27 positive and negative healthy controls. An increase in serum IgA, restricted to subclass IgA1, was found in patients with AS, especially in those with microscopic hematuria. IgA synthesis was not increased, but a significant shift to subclass IgA1 was found. Our results resemble abnormalities previously noted in primary IgA nephropathy, and further support the pathogenetic role of IgA in AS.
我们对患有和未患有镜下血尿的强直性脊柱炎（AS）患者以及HLA - B27阳性和阴性的健康对照者的外周血淋巴细胞免疫球蛋白合成及血清IgA亚类进行了研究。在AS患者中发现血清IgA升高，且仅限于IgA1亚类，尤其是那些有镜下血尿的患者。IgA合成并未增加，但发现向IgA1亚类有显著转变。我们的结果类似于先前在原发性IgA肾病中所观察到的异常情况，并进一步支持了IgA在AS发病机制中的作用。
