强直性脊柱炎中的多克隆B细胞激活
Polyclonal B cell activation in ankylosing spondylitis.
作者信息
Barbieri P, Olivieri I, Benedettini G, Marelli P, Ciompi M L, Pasero G, Campa M
机构信息
Rheumatic Disease Unit, University of Pisa, Italy.
出版信息
Ann Rheum Dis. 1990 Jun;49(6):396-9. doi: 10.1136/ard.49.6.396.
The peripheral blood lymphocyte response of patients with ankylosing spondylitis (AS) to several polyclonal B cell activators was investigated. No differences were found in the reactivity to pokeweed mitogen and protein A between patients and controls; in contrast, the peripheral blood lymphocyte response to Staphylococcus aureus strain Cowan I (SAC) was significantly higher in patients with AS than in controls. This responsiveness was not influenced either by the presence of the HLA-B27 antigen or by environmental factors or associated diseases, and it was higher in patients with active AS than in those with inactive disease. The percentage of circulating B cells was normal. The responses to T cell mitogens and the percentages of T cell subpopulations were similar in patients and in controls. The peripheral blood lymphocyte hyperactivity of patients with AS to SAC was associated with an increased in vitro production of immunoglobulins.
对强直性脊柱炎（AS）患者外周血淋巴细胞对几种多克隆B细胞激活剂的反应进行了研究。患者与对照组对商陆有丝分裂原和蛋白A的反应性未发现差异；相反，AS患者外周血淋巴细胞对金黄色葡萄球菌考恩I株（SAC）的反应明显高于对照组。这种反应性不受HLA - B27抗原的存在、环境因素或相关疾病的影响，且活动期AS患者的反应性高于非活动期患者。循环B细胞百分比正常。患者与对照组对T细胞有丝分裂原的反应以及T细胞亚群的百分比相似。AS患者外周血淋巴细胞对SAC的高反应性与体外免疫球蛋白产生增加有关。
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