Department of Gastroenterology, the First Hospital of Jilin University, Changchun, Jilin, China.
Department of Gastroenterology, the First Affiliated Hospital of Xiamen University, Fujian China.
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820933969. doi: 10.1177/1533033820933969.
Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized. Alternative polyadenylation is an RNA-processing mechanism that generates distinct 3'-termini on messenger RNAs, producing messenger RNA isoforms. Different factors influence the initiation and development of this process. As a key factor in alternative polyadenylation, cleavage factor I m25 plays an important role in messenger RNA maturation and cell signal transduction. Moreover, by regulating the process of alternative polyadenylation, it can inhibit the proliferation, invasion, and metastasis of a variety of tumors. Cleavage factor I m25 also acts as an oncogene in select tumors. The present review focuses on the role of cleavage factor I m25 in solid tumors and treatment. Due to the lack of current knowledge regarding the mechanisms of action and regulation of cleavage factor I m25 and alternative polyadenylation, it is necessary to further examine their role in cancer as well as in other diseases.
分裂因子 I m25 是一种新发现的与实体瘤相关的基因，然而，其在癌症发病机制中的确切作用尚未被阐明。可变多聚腺苷酸化是一种 RNA 加工机制，可在信使 RNA 上产生不同的 3'末端，从而产生信使 RNA 异构体。不同的因素影响这个过程的启动和发展。作为可变多聚腺苷酸化的关键因子，分裂因子 I m25 在信使 RNA 成熟和细胞信号转导中发挥重要作用。此外，通过调节可变多聚腺苷酸化过程，它可以抑制多种肿瘤的增殖、侵袭和转移。分裂因子 I m25 在某些肿瘤中也作为癌基因发挥作用。本综述重点介绍了分裂因子 I m25 在实体瘤和治疗中的作用。由于目前对分裂因子 I m25 和可变多聚腺苷酸化的作用机制和调节知之甚少，有必要进一步研究它们在癌症以及其他疾病中的作用。
