一种靶向线粒体的 Mn(ii)-三联吡啶配合物用于双光子光动力疗法。
A mitochondrion-targeting Mn(ii)-terpyridine complex for two-photon photodynamic therapy.
机构信息
School of Chemical Engineering, Jiangsu Key Laboratory of Function Control Technology for Advanced Materials, Jiangsu Ocean University, Lianyungang 222005, China.
出版信息
Chem Commun (Camb). 2020 Aug 14;56(63):9032-9035. doi: 10.1039/d0cc02051f. Epub 2020 Jul 9.
We developed a mitochondrion-targeting Mn-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate O and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The Mn center of MTP apparently catalyzed the HO-mediated production of ROS and oxygen, which subsequently promoted the O generation, furthering the PDT effect. Additionally, the mitochondrion targeting of MTP provided a good spatial condition for the generation of O, which further promoted the PDT effect.
我们开发了一种靶向线粒体的锰-三联吡啶配合物（MTP），用于双光子光动力治疗。MTP 在近红外区域受到双光子激发以产生 O ，从而产生 PDT 效应。这种 MTP 的使用克服了传统 PDT 剂的缺点。MTP 的 Mn 中心明显催化了 HO 介导的 ROS 和氧气的产生，从而促进了 O 的产生，进一步增强了 PDT 效应。此外，MTP 的线粒体靶向为 O 的产生提供了良好的空间条件，进一步促进了 PDT 效应。
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