School of Chemical Engineering, Jiangsu Key Laboratory of Function Control Technology for Advanced Materials, Jiangsu Ocean University, Lianyungang 222005, China.
Chem Commun (Camb). 2020 Aug 14;56(63):9032-9035. doi: 10.1039/d0cc02051f. Epub 2020 Jul 9.
We developed a mitochondrion-targeting Mn-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate O and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The Mn center of MTP apparently catalyzed the HO-mediated production of ROS and oxygen, which subsequently promoted the O generation, furthering the PDT effect. Additionally, the mitochondrion targeting of MTP provided a good spatial condition for the generation of O, which further promoted the PDT effect.
我们开发了一种靶向线粒体的锰-三联吡啶配合物（MTP），用于双光子光动力治疗。MTP 在近红外区域受到双光子激发以产生 O ，从而产生 PDT 效应。这种 MTP 的使用克服了传统 PDT 剂的缺点。MTP 的 Mn 中心明显催化了 HO 介导的 ROS 和氧气的产生，从而促进了 O 的产生，进一步增强了 PDT 效应。此外，MTP 的线粒体靶向为 O 的产生提供了良好的空间条件，进一步促进了 PDT 效应。
