Arthurs Ross A, Hughes David L, Richards Christopher J
School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TU, UK.
Org Biomol Chem. 2020 Jul 22;18(28):5466-5472. doi: 10.1039/d0ob01331e.
Chiral non-racemic palladacycles were employed as precatalysts for Pd(0) mediated asymmetric synthesis. Addition of HPAr2/base to a ferrocenyloxazoline planar chiral palladacycle resulted in ligand synthesis and palladium capture to give a bidentate Phosferrox/Pd(0) complex. A series of these complexes were generated in situ and applied successfully as catalysts for asymmetric allylic alkylation.
手性非外消旋钯环配合物被用作钯(0)介导的不对称合成的预催化剂。向二茂铁基恶唑啉平面手性钯环配合物中加入HPAr2/碱，可实现配体合成和钯捕获，从而得到双齿Phosferrox/钯(0)配合物。原位生成了一系列此类配合物，并成功地用作不对称烯丙基烷基化反应的催化剂。
