European Centre for Diseases Prevention and Control, Solna, Sweden.
Infect Dis (Lond). 2020 Sep;52(9):625-637. doi: 10.1080/23744235.2020.1766104. Epub 2020 Jun 17.
WHO has set target to reduce mortality attributable to hepatitis B (HBV) and hepatitis C (HCV) by 65% by 2030, with 2015 as baseline. We aimed to describe the European Union/European Economic Area (EU/EEA) baseline mortality from liver diseases, as defined by WHO Core-10 indicator through ICD-10 codes, and estimate mortality attributable to HBV and HCV. Age-standardised mortality rates per 100,000 for hepatocellular carcinoma (HCC, ICD-10 C22.0), chronic liver disease (CLD, ICD-10 K72-K75) and chronic viral hepatitis B and C (CHB/CHC, ICD-10 B18.1-B18.3) were calculated by gender, age-group and country using 2015 Eurostat data. Because aetiology fraction (AF) estimates were lacking for HCC and CLD as defined by C10, number of deaths in EU/EEA countries in 2015 from liver cancer (ICD-10 C22) and 'cirrhosis and other chronic liver diseases' (ICD-10 B18-B18.9, I85-I85.9, I98.2, K70-K70.3, K71.7, K74-K74.9, K75.2, K75.4-K76.2, K76.4-K76.9 and K77.8) were adjusted by corresponding AF estimates from Global Burden of Disease publications. In 2015, there were wide variations across countries in mortality rates from HCC, CLD and CHB/CHC. A 2015 mortality baseline of 63,927 deaths attributable to HBV and HCV is proposed, that includes 55% of liver cancer and 45% of 'cirrhosis and other chronic liver diseases' deaths. The HBV and HCV attributable mortality in the EU/EEA is high. Greater efforts are needed to identify HBV and HCV infections at an early stage and link cases to care to reduce mortality from liver diseases. Country-specific AF estimates are needed to accurately estimate HBV, HCV associated mortality.
世界卫生组织设定了目标，到 2030 年，将乙型肝炎（HBV）和丙型肝炎（HCV）导致的死亡率降低 65%，以 2015 年为基准年。我们旨在描述欧洲联盟/欧洲经济区（EU/EEA）按照世界卫生组织核心 10 项指标，通过国际疾病分类第 10 次修订版（ICD-10）编码定义的肝脏疾病的基线死亡率，并估计乙型肝炎和丙型肝炎导致的死亡率。通过使用 2015 年欧盟统计局的数据，按性别、年龄组和国家计算了每 10 万人中肝细胞癌（ICD-10 C22.0）、慢性肝病（ICD-10 K72-K75）和慢性乙型肝炎和丙型肝炎（CHB/CHC，ICD-10 B18.1-B18.3）的标准化死亡率。由于缺乏按 C10 定义的 HCC 和 CLD 的病因分数（AF）估计数，因此对 2015 年欧盟/欧洲经济区国家因肝癌（ICD-10 C22）和“肝硬化和其他慢性肝病”（ICD-10 B18-B18.9、I85-I85.9、I98.2、K70-K70.3、K71.7、K74-K74.9、K75.2、K75.4-K76.2、K76.4-K76.9 和 K77.8）死亡人数进行了调整，采用了全球疾病负担研究报告中的相应病因分数估计数。2015 年，各国间 HCC、CLD 和 CHB/CHC 的死亡率差异很大。提出了一个 2015 年因乙型肝炎和丙型肝炎导致的 63927 例死亡的基准数，其中包括 55%的肝癌和 45%的“肝硬化和其他慢性肝病”死亡。欧盟/欧洲经济区的乙型肝炎和丙型肝炎导致的死亡率很高。需要加大力度，尽早发现乙型肝炎和丙型肝炎感染，并将病例与治疗联系起来，以降低肝脏疾病的死亡率。需要有国家特定的病因分数估计数，以准确估计乙型肝炎和丙型肝炎相关的死亡率。
